Greenbrier broke out the bats Friday night at Grovetown.
The Wolfpack battered Grovetown pitching for 10 hits, five of which went for extra bases, as they beat the Warriors 9-1.
Among the extra-base hits was a monster two-run homer over the right-field fence by Adam Sasser and a solo shot to dead center by Clint Hardy.
"We hit a couple of big home runs when we needed to and sometimes you've got to do that," said Greenbrier head coach Chris Wilkins.
The Wolfpack improved to 10-3, 6-1 in the region and can clinch first with a win in one of its last two region games. The Wolfpack can finish no worse than second, ensuring they will host at least one series in the region tournament.
Sasser and Taylor Glover were the main thorns in the Warriors' side.
Glover had three singles and a double, scoring three times, while Sasser added two doubles and his home run.
Hardy (2-0) got the start for the Wolfpack, working 4 2/3 innings while giving up one run (unearned) on three hits while striking out two. "Today was to see where he was at and he did a good job," said Wilkins.
In the fifth inning, Wolfpack center fielder Chris Michals robbed Michael Cornett of a base hit with a diving catch, then threw out a runner at the plate two batters later, helping limit the Warriors (7-7, 1-6) to one run in the inning.
Leading 7-1, Hardy added to the total leading off the sixth inning as he blasted a pitch over the fence in straightaway center field.
The Warriors defense didn't help Busby (1-2) as they committed four errors behind him.
"When you're playing a team like Greenbrier, and as hot as they are right now, you gotta play good defense," said Warriors head coach Mike Jones.