A four-story building being demolished on the edge of downtown collapsed with a thunderous boom Wednesday, raining bricks down on a thrift store, injuring 12 people and trapping two others, the fire commissioner said.

Three days into Pfc. Bradley Manning's court-martial over giving thousands of classified documents to WikiLeaks, the case against him is becoming clear: Prosecutors are calling witnesses who say Manning was trained to guard classified information and knew it could easily fall into enemy hands, yet he defied orders to keep it protected.

Tenacity marked U.S. Sen. Frank Lautenberg's journey from a childhood so poor his family couldn't afford his bar mitzvah to his life as a multimillionaire businessman who served for decades in the Senate, relatives and dignitaries said Wednesday at his funeral at a New York City synagogue.

Susan Rice, tapped by President Barack Obama to become the next National Security adviser, has been at the center of the international feuding over Syria's disastrous civil war as the outspoken U.S. ambassador at the United Nations.

The memorial for four Houston firefighters killed battling a hotel blaze ended with the mournful sound of bagpipes.

New Mexico authorities say an Albuquerque man stabbed and kidnapped his mother, then threw her off a bridge into the Rio Grande.

Prosecutors in the trial of an ex-Houston police officer accused of taking part in the 2010 videotaped beating of a black teenage burglary suspect have rested their case.

Susan G. Komen for the Cure says it is canceling half of its 3-day charity races next year because of a drop in participation levels.

A woman from a wealthy New York suburb is accused of growing and attempting to sell nearly 3,000 marijuana plants from a city warehouse.

Officials at the last hospital still closed because of damage from Superstorm Sandy are no longer predicting when they will be able to reopen.

A Detroit police officer on Wednesday defended his decision to not arrest a murder suspect a few hours before a raid to snare the man led to the death of a sleeping 7-year-old girl.

A track inspection found problems two days before a train derailed in Connecticut and injured more than 70 people, the National Transportation Safety Board said Wednesday.

A southeast Missouri man plans to plead guilty to murder in the killing of his estranged wife, a mother of triplets who was missing for almost two years, his lawyer said Wednesday.

A four-story building being demolished collapsed Wednesday on the edge of downtown, injuring 12 people and trapping two others, the fire commissioner said.

Tenacity marked U.S. Sen. Frank Lautenberg's journey from a childhood so poor his family couldn't afford his bar mitzvah to his life as a multimillionaire businessman who served for decades in the Senate, relatives and dignitaries said Wednesday at his funeral at a New York City synagogue.

The American soldier charged with killing 16 Afghan civilians during nighttime raids on two villages last year has begun describing the attacks, explaining to a judge that he shot each victim.

Staff Sgt. Robert Bales, the American soldier from Lake Tapps, Ohio, charged with killing 16 Afghan civilians during nighttime raids on two villages last year, pleaded guilty Wednesday to avoid the death penalty. This is what AP reporters and photographers at Joint Base Lewis-McChord south of Seattle are learning about the events unfolding (in PDT):

If you're weary of Mini Coopers described as "cute," the new-for-2013 Mini Cooper Paceman is for you.